The burden of cytomegalovirus infection remains high in high?risk kidney transplant recipients despite six?month valganciclovir prophylaxis

Cytomegalovirus continues to be a concern after transplantation despite prophylaxis regimens. Our aim was analyse post-prophylaxis primary cytomegalovirus infections among kidney transplant recipients 6-month valganciclovir and determine the usefulness of surveillance prophylaxis. Data from all D+/R- January 2004 October 2018 at our center who received with were retrospectively analysed (N = 481). Detailed analyses performed for 136 patients monitored every 2-4 weeks DNAemia discontinuation Post-prophylaxis infection occurred in 182/481 (38%) median 264 days (IQR: 226-367) 84 end 46-187). In 49% patients, over 3 months not associated lower patient or graft survival no independent risk factors found. From closely, 71/136 (52%) developed infection. Altogether, 52/136 diagnosed probable disease 19/136 (14%) had asymptomatic CMV Recurrent 38/71 (39%) patients. The incidence remains high Surveillance challenging as considerable portion late already symptomatic.